This study guide provides an overview and contains practice questions that can help make the learning process easier for you. So if you’re ready, let’s get started.
What are Inhaled Anti-Infective Agents?
An Anti-Infective Agent is a general term that describes any drug that works to fight the spread of an infectious organism. This class of medication includes antiviral, antifungal, and antituberculosis agents.
Types of Inhaled Anti-Infective Agents:
Here is a list of some of the most common examples of inhaled corticosteroids:
- Tobramycin (TOBI)
- Pentamidine (NebuPent)
- Ribavirin (Virazole)
- Zanamivir (Relenza)
- Aztreonam (Cayston)
In the list, the generic name was provided first, followed by the brand name. Keep in mind that other inhaled anti-infective agents may exist. These are just a few of the most common examples.
Anti-Infective Agents Practice Questions:
1. What is an Anti-infective agent?
They are substances that act against or destroy infections
2. What alternate therapy is most likely prescribed for a patient with pneumocystis pneumonia, who is unable to tolerate trimethoprim-sulfamethoxazole therapy?
3. What drug will a respiratory therapist use as an alternative to intravenous therapy in a patient with cystic fibrosis to manage a chronic Pseudomonas aeruginosa infection?
4. What aerosolized anti-infective agents are used in the airway management of a patient with cystic fibrosis who has had the Pseudomonas aeruginosa infection?
Inhaled tobramycin (TOBI) and inhaled aztreonam (Cayston).
5. What agent is used in the treatment and prophylaxis of H1N1 influenza A?
6. What are the possible side effects observed in a patient under parenteral pentamidine therapy?
Leukopenia, hypoglycemia, and abscess formation.
7. What is an antiprotozoal aerosolized anti-infective agent?
Pentamidine isethionate (NebuPent).
8. What medication is beneficial for a patient diagnosed with bronchiolitis caused by respiratory syncytial virus (RSV)?
9. What drug prevents bronchoconstriction in a patient with pneumocystis pneumonia (PCP) and is under aerosolized pentamidine therapy?
10. A physician prescribes nebulized tobramycin to a patient. For what conditions does a respiratory therapist check the patient’s medical history before administration?
Renal impairment, vestibular problems, and neuromuscular dysfunction.
This book (in paperback format) has sample TMC Practice Questions on the topic of Pharmacology.
11. What aerosolized medication would be used to treat a patient with acquired immunodeficiency syndrome (AIDS) who has opportunistic pneumonia caused by pneumocystis jiroveci?
Pentamidine isethionate (NebuPent).
12. What aerosolized medication should a respiratory therapist prescribe while treating an 8-year-old child with acute, community-acquired, atypical pneumonia caused by influenza A?
13. What systemic side effects are most likely to have occurred in a patient who was switched from parenteral pentamidine (Pentacarinat) therapy to aerosolized pentamidine (NebuPent) to prevent systemic side effects?
Leukopenia, hypotension, and hepatic dysfunction.
14. What possible pulmonary side effects are observed in a patient on aerosolized ribavirin therapy?
Apnea, pneumothorax, and bacterial pneumonia.
15. What are the systemic reactions that are observed in a patient under aerosolized pentamidine therapy?
Dysglycemia, conjunctivitis, and renal insufficiency.
16. What is an indication for Aztreonam?
To improve pulmonary symptoms in cystic fibrosis patients with pseudomonas aeruginosa.
17. What is Tobramycin?
It is the drug we typically give to cystic fibrosis patients. Its brand name is TOBI and Bethkis. The dose is 300 mg/ 5ml ampule. Its clinical use is to treat Pseudomonas aeruginosa in Cystic fibrosis.
18. What is Pentamidine isethionate?
Brand name: NebuPent; dosage: 300 mg of powder in 6 ml of sterile water; 300 mg once every 4 weeks; and, clinical use: PCP prophylaxis.
19. What is Ribavirin?
Brand name: Virazole; dosage: 6 mg of powder in 300 ml of sterile water (20-mg/mL solution) given 12-18 hr. /day for 3-7 days by SPAG-2 neb; and, clinical use: RSV. It is used with RSV (respiratory syncytial viral) infections in children and infants at risk for severe or complicated disease, influenza, and the herpes simplex virus.
20. What is Aztreonam?
Brand name: Cayston; dosage: 75 mg/1mL; adults and children over 7 years: 75mg TID, 28 days on 28 days off; and, clinical use: Pseudomonas
21. What is Zanamivir?
Brand name: Relenza; DPI: 5mg/inhalation; adults and children over 5: 2 inhalations (one 5-mg blister per inhalation) BID less than 12 hours apart for 5 days; and, clinical use: Influenza. It is an Antiviral agent approved for use in the treatment of uncomplicated influenza illness in adults and children older than 7 years during early onset (within the first 2 days) of infection.
22. What is Aerosolized Pentamidine used for?
Prevention of PCP (Pneumocystis pneumonia is a fungus) in
23. What is the Pentamidine brand name?
24. What is a Pentamidine nebulizer?
Respirgard II (no medication can escape because of the expiratory filter, thumb port,
25. What is the Pentamidine Dose in dry powder?
300mg in 6 mL of sterile water every 4 weeks.
26. What is the description of the Pentamidine administration?
It should not be exposed to the medication. It is given with the Respirgard II nebulizer at a flow rate of 5-7L/min from 50 psi gas source.
27. What are the Pentamidine side effects?
Parenteral: Hypoglacemia, impaired renal function; aerosol: Cough, bronchospasm, shortness of breath, bronchial irritation, and wheezing, spontaneous pneumothoraces; and, should be used with B-adrenergic bronchodilator before inhaling aerosolized pentamidine.
28. What is the Ribavirin brand name?
29. What is the Ribavirin nebulizer?
The SPAG II (1.3
30. What is the normal Ribavirin Dose?
20mg/ml 12-18 hours per day; minimum 3 days; and, maximum 7 days.
31. What is the Respiratory Syncytial Virus (RSV)?
It is a virus that can cause bronchiolitis and pneumonia. It is seasonal in nature and the peak occurs during winter months. RSV sticks to cells changing their shape and this produces very sticky mucus.
32. Can you administer Ribavirin to infants?
Manufacturers warn against the administration of the drug to infants on mechanical ventilation.
33. What are the side effects of Ribavirin?
Pulmonary: worsening of asthma or COPD; cardiovascular: hypotension, cardiac arrest; hematologic: blood cells; dermatologic/topical: rash, conjunctivitis; and, equipment-related: impairment of expiratory valves and sensors.
34. What is the Palivizumab brand name?
35. What are the side effects of Palivizumab?
Anaphylaxis, fever, upper respiratory infection, otitis media, rhinitis, rash, and coughing/wheezing.
36. How is Aztreonam administered?
Each patient should be pretreated with bronchodilator before each dosing. Any prescribed mucolytic should also be given before Cayston and should be refrigerated.
37. What is the Aztreonam mode of action?
In vitro activity against gram-negative aerobic bacteria and binds to penicillin-binding proteins of pathogens, such as Pseudomonas
38. What are the Aztreonam side effects?
Injectable aztreonam has caused severe allergic reactions and nebulized: bronchospasm and decrease patient’s FEV1.
39. How to prevent the Aztreonam environmental effects?
Use expiratory filters with one-way valves and thumb control.
40. What are the Zanamivir side effects?
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41. What are the clinical indications from pentamidine?
Prevention of pneumocystis pneumonia (PCP) in HIV infected patients.
42. What is Ribavirin given for?
43. What is Tobramycin given for?
44. What is another name for Aztreonam and what is it given for?
Cayston; and it is given for Pseudomonas
45. What is the Pentamidine mode of action?
Unknown but may block RNA and DNA synthesis.
46. What are the RSV resulting diseases?
It can cause bronchiolitis and pneumonia, mainly in children. Outbreaks occur in the late fall through the early spring.
47. What is the Ribavirin mode of action?
It is unknown.
48. What is the Zanamivir mode of action?
Binds to enzyme neuraminidase thus blocking
49. What is the Aztreonam mode of action?
Inhibits bacterial cell wall synthesis and ultimately death of the cell.
50. What are the Pentamidine aerosol side effects?
SOB, cough, bad taste, bronchospasms and wheezing,
51. What are the Relenza limitations?
DPI for children age 5 and above and adults.
52. What is the Respirgard II Neb used for?
53. What is the SPAG used for?
For Ribavirin (Virazole).
54. What are the indications for Pentamidine?
Prevention of Pneumocystis pneumonia (PCP) in HIV patients.
55. What is the Pentamidine brand name?
56. What is the description of the Pentamidine aerosol administration?
It is for Prophylactic Therapy and for Local targeted lung delivery. Fewer or less severe side effects compared with systemic administration.
57. What is the Pentamidine dose?
300 mg given by inhalation once every 4 weeks, dry powder, 300 mg/vial, reconstituted with 6 mL of sterile water and not saline (can cause precipitation).
58. What is the description of the Pentamidine administration?
Powered by a flow rate of 5-7 L/min from 50-psi gas source, escaped particles may be filtered to limit exposure of healthcare workers, nebulizer performance and mass median diameter (MMD) of 1-2 μm.
59. What is the Pentamidine nebulizer name?
Respirgard II (manual system with thumb port).
60. What are the side effects of Pentamidine?
Hypoglycemia (up to 62% of patients) with cumulative cytotoxic effect on pancreatic beta cells; impaired renal function and azotemia; cough and bronchial irritation; shortness of breath; bronchospasm and wheezing; and, spontaneous pneumothoraces.
61. What are the environmental precautions of Pentamidine?
Use nebulizer system with one-way valves and expiratory filter; stop nebulization if patient takes
62. What is the description of the Aerosol Therapy for Pentamidine?
Oral trimethoprim-sulfamethoxazole (TMP-SMX) preferred for prophylaxis of PCP, as long as adverse side effects from TMP-SMX were absent or acceptable.
63. What are the Ribavirin indications (aerosolized)?
Treatment of hospitalized infants with severe lower respiratory tract infection caused by
64. What is Respiratory Syncytial Virus (RSV)?
It can take over only on children
65. What is the mechanism of action of Ribavirin?
66. What is the Ribavirin dose?
20-mg/mL solution; 12 to 18 hour/day; minimum of 3 days; not more than 7 days; supplied as 6g of powder in
67. What is the Ribavirin nebulizer?
SPAG (Large volume, pneumatically powered nebulizer); approximately 1.3 μm, MMD; and, solutions in the SPAG reservoir should be replaced after 24 hours.
68. What are the pulmonary side effects of Ribavirin?
Deterioration of pulmonary function and worsening of asthma or chronic obstructive disease; pneumothorax, apnea, and bacterial pneumonia.
69. What are the cardiovascular side effects of Ribavirin?
Cardiovascular instability, including hypotension, cardiac arrest, and digitalis toxicity.
70. What are the hematological side effects of Ribavirin?
Effects on blood cells have been reported with
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71. What are the dermatological/topical side effects of Ribavirin?
Rash, eyelid erythema, and conjunctivitis.
72. What are the equipment-related side effects of Ribavirin?
Occlusion and impairment of expiratory valves and sensors with ventilator use and endotracheal tube blockage from drug precipitate.
73. What is the environmental contamination concern with aerosolized ribavirin?
Potential for mutagenic and carcinogenic effects; effect on fertility is uncertain caused testicular lesions in rats; and, effect on pregnancy is of particular concern and use as last line of defense.
74. What are the Palivizumab indications?
Prevention of serious lower respiratory tract disease caused by RSV in children and infants at high risk. Safety and efficacy established for infants with BPD, premature infants (<35 weeks), and children with congenital heart disease.
75. What are the indications for Tobramycin?
Management of chronic Pseudomonas
76. What is the indication for Virostatic?
Stopping a virus from replicating.
77. What is the indication for Virucidal?
Killing a virus.
78. What is the Aztreonam brand name?
79. What is the Zanamivir brand name?
80. What is the Tobramycin brand name?
TOBI and Bethkis.
So there you have it. That wraps up our study guide on Anti-Infective agents and medications. Hopefully, this material can help you develop a better understanding of this topic.
We also have a similar guide on the topic of Antimicrobial Agents that I think you will enjoy. Thank you so much for reading and as always, breathe easy my friend.
The following are the sources that were used while doing research for this article:
- Faarc, Gardenhire Douglas EdD Rrt-Nps. Rau’s Respiratory Care Pharmacology. 10th ed., Mosby, 2019. [Link]
- Faarc, Kacmarek Robert PhD Rrt, et al. Egan’s Fundamentals of Respiratory Care. 12th ed., Mosby, 2020. [Link]
- “Antimicrobial Peptides as Anti-Infective Agents in Pre-Post-Antibiotic Era?” PubMed Central (PMC), 1 Nov. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6887943.
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