Question Answer
What are the two forms that O2 is carried in? 1)dissolved O2 in the blood plasma? 2)chemically bound to Hb
What are the normal values for an arterial blood gas? ph- 7.35-7.45, PCO2-35-40mmHg(PaCO2), HCO3 – 22-28 mEg/L, PO2 – 80-100 mmHg (PaO2)
What are the normal values in a venous blood gas? pH – 7.30-7.40, PCO2 – 42-48 mmHG (PVCO2), HCO3 – 24-30mEq/L, PO2 – 35-45mmHg (PVO2)
At normal BTPS, How many mL of O2 will dissolve in 100mL of blood for every 1 mmHG of PO2? What law is this? 0.003, Henry’s Law
What does Hb A consist of: 1)4 heme groups 2)4 amino acid chains (polypeptide chains)
What is a globin? a protein
how many oxygen molecules can a combine with Hb? 4, one per heme/iron group
What is the term used for Hb + O2? oxyhemoglogin
what is the term used for Hb not bound with O2? reduced Hb / deoxyhemoglobin
What two identical chains does the Hb molecule consist of? 2 alpha (141 amino acids),2 Beta ( 146 amino acids)
What does the normal Fetal Hb consist of? 2 alpha chains, 2 gamma chains
What is fetal Hb replaced with gradually? How long does it take? Hb A, happens over the first year of postnatal life
normal Hb is capable of carrying how many vol% 0.3vol%
What is Hb S? What is effected in this Hb? sickle cell Hb, it has a different AA substituted in the beta chain: causes the deoxygenated Hb to change the shape of the RBC to sickle shape.
What is the term used for Hb + O2? oxyhemoglogin
what is the term used for Hb not bound with O2? reduced Hb / deoxyhemoglobin
What two identical chains does the Hb molecule consist of? 2 alpha (141 amino acids),2 Beta ( 146 amino acids)
What does the normal Fetal Hb consist of? 2 alpha chains, 2 gamma chains
What is fetal Hb replaced with gradually? How long does it take? Hb A, happens over the first year of postnatal life
normal Hb is capable of carrying how many vol% 0.3vol%
What is Hb S? What is affected in this Hb? sickle cell Hb, it has a different AA substituted in the beta chain: causes the deoxygenated Hb to change the shape of the RBC to sickle shape.
What is the term used for Hb + O2? oxyhemoglogin
what is the term used for Hb not bound with O2? reduced Hb / deoxyhemoglobin
What two identical chains does the Hb molecule consist of? 2 alpha (141 amino acids),2 Beta ( 146 amino acids)
What does the normal Fetal Hb consist of? 2 alpha chains, 2 gamma chains
What is fetal Hb replaced with gradually? How long does it take? Hb A, happens over the first year of postnatal life
normal Hb is capable of carrying how many vol% 0.3vol%
What is Hb S? What is affected in this Hb? sickle cell Hb, it has a different AA substituted in the beta chain: causes the deoxygenated Hb to change the shape of the RBC to sickle shape.
Waht is the normal Hb Value of an ADULT MALE? 14-16g/100ml
What is the normal Hb value an ADULT FEMALE? 12-15g/100ml
What is the normal Hb value for an infant? 14-20g/100ml
What % of an RBC’s wirght is Hb? 33%
What are your 3 physiological shunts? Thebesian venous drainage into left atrium, Brobchiole venous drainage into pulmonary veins & Alveolar that are under ventilated relative to pulmonary blood.
CaO2 (O2 Content of arterial blood) Formula = (Hb * 1.34 * SaO2)+(PaO2 * 0.003)
CvO2 (O2 Concentration of mixed venous blood) Formula = (Hb * 1.34 * SvO2)+(PvO2 * 0.003)
CcO2 (O2 Content of pulmonary capillary blood) Formula = (Hb * 1.34)+(PAO2 * 0.003)
What causes the O2 dissociation curve to shift to the left? Increased pH, Decreased PcO2, Decreased Temp, Decreased 2,3-DPG
What causes the O2 dissociation curve to shift to the right? Decreases pH, Increased PcO2, Increased Temp, Increased 2,3-DPG
What is P50? A point of reference on the curve that represents the partial pressure at which Hb is 50% saturated with O2.
Waht is the normal Hb Value of an ADULT MALE? 14-16g/100ml
What is the normal Hb value an ADULT FEMALE? 12-15g/100ml
What is the normal Hb value for an infant? 14-20g/100ml
What % of an RBC’s wirght is Hb? 33%
What are your 3 physiological shunts? Thebesian venous drainage into left atrium, Brobchiole venous drainage into pulmonary veins & Alveolar that are under ventilated relative to pulmonary blood.
CaO2 (O2 Content of arterial blood) Formula = (Hb * 1.34 * SaO2)+(PaO2 * 0.003)
CvO2 (O2 Concentration of mixed venous blood) Formula = (Hb * 1.34 * SvO2)+(PvO2 * 0.003)
CcO2 (O2 Content of pulmonary capillary blood) Formula = (Hb * 1.34)+(PAO2 * 0.003)
What causes the O2 dissociation curve to shift to the left? Increased pH, Decreased PcO2, Decreased Temp, Decreased 2,3-DPG
What causes the O2 dissociation curve to shift to the right? Decreases pH, Increased PcO2, Increased Temp, Increased 2,3-DPG
What is P50? A point of reference on the curve that represents the partial pressure at which Hb is 50% saturated with O2.
What is the normal range for P50? 27 mmHg
What happens to P50 when the O2 dissociation curve shifts to the right? Affinity of Hb for O2 decreases so Hb is less saturated at a given PO2 causing P50 to increase.
What happens to P50 when the O2 dissociation curve shifts to the left? Affinity of Hb for O2 increases so Hb is more saturated at any given PO2 causing P50 to decrease.
What does Hypoxia do to the 2,3-DPG level regardless of the cause? It causes it to increase
Why do anemic patients not show signs and symptoms of Hypoxia? Because the 2,3-DPG level increases as Hb concentration decreases
What is 2,3-DPG? A metabolic intermediary that is formed by RBCs during anaerobic glycolysis.
What is the Bohr Effect? Effect of PcO2 and pH on the oxyhemoglobin curve.