Is COVID-19 Making a Comeback Vector

Is COVID-19 Making a Comeback in 2025?

by | Updated: Jun 7, 2025

As 2025 unfolds, concerns about a resurgence of COVID-19 have emerged, prompting health officials and the public to assess the current situation and potential risks. While the pandemic’s acute phase has subsided, the virus continues to circulate, with varying levels of activity across different regions.

Current Trends and Transmission Rates

Recent data from the Centers for Disease Control and Prevention (CDC) indicates that as of December 3, 2024, COVID-19 infections are growing or likely growing in 28 states, declining or likely declining in 3 states, and remaining stable in 17 states.

The effective reproduction number (Rt), which estimates the average number of new infections caused by each infectious person, shows that in many areas, Rt is above 1, suggesting an increase in transmission.

Seasonal Patterns and Variants

COVID-19 has exhibited seasonal fluctuations, with peaks typically occurring in winter months. However, data from the past four years reveal that the virus can also surge during summer, as seen in July and August of 2023.

The emergence of new variants, such as the XEC strain identified in 2024, has contributed to increased transmission rates. Although XEC is not believed to be more deadly than previous variants, its higher transmissibility has raised concerns among health officials.

Vaccination Efforts and Public Health Measures

In response to these developments, updated COVID-19 vaccines have been made available for the 2024-2025 season. These vaccines aim to provide protection against severe illness, hospitalization, and death related to COVID-19.

Health authorities continue to emphasize the importance of vaccination, especially for vulnerable populations, to mitigate the impact of potential surges.

Global Perspective and Future Outlook

The World Health Organization (WHO) has transitioned from emergency response to long-term COVID-19 disease management, reflecting the virus’s shift toward endemicity. This approach focuses on sustaining gains made during the pandemic and integrating COVID-19 control into routine public health practices.

Experts acknowledge that while COVID-19 may not be eradicated, its impact can be managed through vaccination, public health interventions, and ongoing surveillance.

As of 2025, COVID-19 remains a public health concern, with periodic increases in transmission influenced by seasonal patterns and emerging variants. Continued vigilance, vaccination efforts, and adherence to public health guidelines are essential to control the virus’s spread and minimize its impact on society. Staying informed and proactive will be crucial in navigating the evolving landscape of COVID-19.

Key Takeaways:

  • Rising COVID-19 Cases: As of 2025, COVID-19 transmission rates are increasing in several U.S. states, with concerns about new surges in winter and summer seasons.
  • Seasonal Patterns and Variants: The virus continues to show seasonal fluctuations, with new variants like XEC contributing to increased transmissibility.
  • Updated Vaccines Available: Updated COVID-19 vaccines for the 2024-2025 season are available, offering protection against severe illness, hospitalization, and death.
  • Global Management Strategy: The World Health Organization has shifted from emergency response to long-term COVID-19 management, treating the virus as endemic.
  • Public Health Recommendations: Health officials stress the importance of vaccination, especially for vulnerable populations, to reduce the virus’s impact.
  • Uncertain Future Outlook: While COVID-19 may not be eradicated, experts believe its impact can be managed through ongoing vaccination efforts, monitoring, and public health measures.
John Landry RRT Respiratory Therapy Zone Image

Written by:

John Landry, BS, RRT

John Landry is a registered respiratory therapist from Memphis, TN, and has a bachelor's degree in kinesiology. He enjoys using evidence-based research to help others breathe easier and live a healthier life.