If you’re a Respiratory Therapy student looking to learn about Xanthine drugs, then this is the post for you. As you will see below, we have put together a study guide that is loaded with Xanthine drugs practice questions and more. 

Xanthines are a class of medication that you will need to be familiar with as a Respiratory Therapist, and it all starts now while you’re taking your Pharmacology course in school. So if you use this study guide now, you can build a nice foundation of knowledge for years to come. Let’s dive in!

Xanthine Drugs Practice Questions:

1. What are xanthines?
They are also called methylxanthines and are considered to be ‘side-door’ or secondary bronchodilators.

2. What are some examples of xanthines?
Theophylline, caffeine, and theobromine.

3. What are the uses of xanthines?
Asthma management, COPD management, and Apnea of prematurity.

4. What is caffeine citrate?
It is the drug of choice for apnea of prematurity.

5. What are the effects of xanthines?
CNS stimulant, smooth muscle relaxation, diuresis, and cerebral vasoconstriction.

6. What are the serum levels of theophylline?
5 to 10 for COPD, 5 to 15 for asthma and keep under 20, in general.

7. What are the side effects of xanthines?
Nausea, vomiting, diuresis, hypotension, cardiac arrhythmias, headaches, and tremors.

8. What is the therapeutic range of theophylline?
10 to 20 mcg/ml.

9. What are the three bronchodilators used for the lower respiratory tract?
Xanthine derivatives, sympathomimetics/beta-adrenergic agonists, and anticholinergics.

10. What do xanthine drugs do?
Xanthines have a direct effect on the smooth muscles of the respiratory tract and blood vessels and it provides symptomatic relief or prevention of bronchial asthma.

11. What is the prototype for xanthines?
Theophylline (Slo-bid, Theodor) and aminophylline (somophylline) IV use.

12. What are xanthines primarily used for?
It is primarily used for prevention of asthma symptoms and relief of acute asthma attacks and it is readily absorbed from GI tract and can be taken with food.

13. What are the major adverse effects of xanthines?
GI: N/V/D and anorexia (first sign of toxicity); CV stimulation: tachy-dysrhythmias, angina, hypotension, palpitations; and, CNS: seizures -tremors (late sign of toxicity).

14. What is caused by xanthines which resemble adrenergic medicines?
Neurologic stimulation.

15. What is the serum level of theophylline?
10-20 mcg/mL.

16. Why are levels drawn at first dose when taking xanthine?
Because there is no antidote so standard first aid measured must be used: charcoal, gastric lavage and emesis.

17. What should be monitored when taking xanthines?
Monitor HR, RR, BP (resemble adrenergics) and monitor ECG for rhythm changes (CV stimulation).

18. How are xanthines used in asthma?
Theophylline is used as a maintenance therapy and is used for patients older than 5 years of age.

19. How are xanthines used in COPD?
Theophylline is recommended as an alternative to B2-agonists and anticholinergics. It is not to be used in acute exacerbations.

20. How are xanthines used in apnea of prematurity?
First line treatment and theophylline most extensively used in the past, but caffeine citrate may be a better choice (safer and higher therapeutic index).

21. Where does theophylline come from?
Tea leaves.

22. Where does theobromine come from?
Cocoa seeds or beans.

23. What are the effects xanthines on humans?
CNS stimulation, cardiac muscle stimulation, diuresis, bronchial, uterine, vascular smooth muscle relaxation (theophylline is classified as a bronchodilator), peripheral, coronary vasodilation and cerebra vasoconstriction (used in headache remedies).

24. Why do we titrate theophylline doses?
Individuals metabolize theophylline at different rates and difficult to determine therapeutic doses.

25. What is the therapeutic action of xanthines?
Effect on smooth muscles of the respiratory tract.

26. What is the pharmacokinetics of xanthines?
Rapidly absorbed from the GI tract, widely distributed and metabolized in the liver, excreted in the urine.

27. What are the adverse effects of xanthines?
Theophylline levels: GI upset, irritability, tachycardia, seizures, brain damage, and death.

28. What are the contraindications for xanthines?
GI issues, coronary disease, respiratory dysfunction, renal/hepatic disease, alcoholism and hyperthyroidism.

29. What is theophylline?
Brand names: Theochron, Elixophyllin, Theo-24; and, formulations: tablets, capsules, syrup, elixir, extended-release tablets, capsules, and injections.

30. What is oxtriphylline?
Brand names: Choledyl SA; and, formulations: tablets, syrup, elixir, and sustained release tablets

31. What is aminophylline?
Brand names: Aminophylline; and, formulations: tablets, oral liquid, injection, and suppositories.

32. What is dyphylline?
Brand names: Lufyllin; and, formulations: tablets and elixir.

33. What are some common side effects of xanthines?
Gastric upset, headache, anxiety, irritability, tachycardia, seizures and diuresis.

34. How are xanthines commonly used in apnea of prematurity?
Caffeine citrate is preferred over theophylline and loading dose of 20mg/1kg, then 5mg/kg daily.

35. What is the rapid theophyllinization dosage?
Oral loading dose of 5mg/kg of ideal body weight.

36. What is the slow theophyllinization dosage?
The initial dose of 16mg/kg/ 24 hr or 400mg/24 hour and choose whichever less is.

37. What is a methylxanthine (xanthine)?
They are inhibitor drugs that indirectly increase the amount of cAMP in smooth muscles. They are given by tablet, IV or injection.

38. What is apnea of prematurity?
When a premature baby is born they have a tendency to not breathe.

39. What are the two main drug classifications of xanthines?
Theophylline and caffeine.

40. What are some of the physiologic effects of xanthines that have generally stimulant properties?
CNS stimulation, cardiac muscle stimulation, bronchial smooth muscle relaxation, cerebral vasoconstriction, and diuresis.

41. What is the safe therapeutic blood level of theophylline?
10-20 mcg/ml to optimize bronchodilation.

42. What level should theophylline is kept at for neonates and children?
5-10 mcg/ml.

43. When can theophylline toxicity occur?
When the serum level exceeds 20 mcg/ml.

44. What are the signs of theophylline toxicity?
Tremors, nausea, vomiting, seizures, tachycardia and arrhythmias.

45. What examples are theophylline and caffeine?

46. What condition do premature neonates have to use theophylline and caffeine for treatment?

47. If COPD patient is using combivent and is also taking inhaled corticosteroids, what could be recommended as long as the patient is not experiencing an acute exacerbation?

48. What type of drugs are xanthines?
A third class drug.

49. What is the mechanism of action of xanthines?
It is unclear, unfortunately.

50. Alkaline substances from plants which when reacted with acids form salts?

51. What are drugs derived from xanthines?

52. What enzymes changes intracellular signaling?

53. What is the xanthine of choice to treat apnea of premature neonates?
Caffeine citrate.

54. If you are working in the neonatal intensive care unit and discover your patient has apnea of prematurity, you should suggest a plan for dosing what?
Caffeine citrate.

55. How does caffeine citrate work in infants?
Stimulates breathing and has a high therapeutic index with fewer side effects than theophylline.

56. Why is theophylline classified as a bronchodilator?
It has a relaxing effect on bronchial smooth muscles.

57. What are the three main physiological effects produced by xanthines?
Cardiac muscle stimulation, central nervous system stimulation, and bronchial smooth muscle relaxation.

58. What are three possible theories explaining how theophylline works?
Inhibition of phosphodiesterase, antagonism of adenosine, and catecholamine release.

59. What two things are stimulated by caffeine?
Skeletal muscles and the central nervous system.

60. Why is it difficult to determine the therapeutic doses of theophylline?
Because individuals metabolize theophylline at different rates.

61. What is 5 mg/kg known as?
Ideal body weight.

62. What is 100% theophylline known as?
Anhydrous theophylline.

63. What is the current recommended blood serum theophylline level for the management of asthma?
5-15 ug/mL

64. What is the current recommended blood serum theophylline level for the management of COPD?
5-10 ug/mL.

65. How is the dosage of theophylline best monitored?
By measuring serum drug levels.

66. What is a significant side effect of theophylline?

67. What includes less toxic side effects of theophylline therapy?
Headache, diuresis, tachypnea, palpitations, and vomiting.

68. What will cause an increase in blood theophylline levels?
Renal failure.

69. What three conditions increase theophylline blood levels?
Pneumonia, corticosteroids, and Beta-blockers.

70. What are five disadvantages of theophylline therapy?
Narrow therapeutic margin, toxic effects, unpredicted blood levels, need for individual dosing, and numerous drug-drug and drug-condition interactions.

71. What are five factors that will increase theophylline levels?
Alcohol, Beta-blocking agents, zileuton, calcium channel blockers, and influenza virus vaccine.

72. What are three factors that will decrease theophylline levels?
Isoniazid, loop diuretics, and rifampin.

73. What two things does theophylline increase within respiratory muscles?
Strength and endurance.

74. What are the three anti-inflammatory effects of theophylline?
Decreased migration of activated eosinophils into bronchial mucosa, inhibition of pro-inflammatory cytokines, and reduced airway responsiveness to stimuli such as histamine and methacholine.

75. What four main side effects of theophylline?
Restlessness, superventricular tachycardia, hypotension, and nausea.

76. What four things do theophylline produces within the body?
Increased phrenic nerve activity, anti-inflammatory effect, increased ventilatory drive, and increased respiratory rate.

Final Thoughts

So there you have it! I hope this study guide about the different Xanthine drugs was helpful for you. Again, if you go through these practice questions again and again, you will absolutely learn everything you need to know for, not only Respiratory Therapy school, but for your career in the future as well. Thanks for reading and as always, breathe easy my friend.